Weekly Spotlight - 14.11.24

CAR T-cell trials, memory B cells, gene biomarkers, and research breakthroughs.

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In the News

Seattle Children's Launches CAR T Cell Trial for Paediatric Lupus Patients

Seattle Children's is enrolling participants for the first U.S. CAR T cell trial for children with lupus. The REACT-01 trial aims to help those aged 2-30 with treatment-resistant lupus. This innovative therapy targets immune cells to reset the system, offering hope for improved outcomes.

Memory B Cells' Role in Systemic Lupus Erythematosus Pathogenesis

Memory B cells play a crucial role in systemic lupus erythematosus (SLE) by being unresponsive to B cell receptor signals but reactive to Toll-like receptors and T cell interactions. This dysfunction contributes to SLE pathology. Targeting these cells may offer effective treatment, avoiding broader B cell depletion side effects.

Lupus Researchers Honoured for Groundbreaking Contributions to Medical Science

Dr. Brad H. Rovin and Dr. Alí Duarte-García are honoured for their significant contributions to lupus research. Dr. Rovin's work focuses on lupus nephritis, while Dr. Duarte-García's research addresses lupus classification and treatment. Their achievements inspire hope and progress in understanding and managing lupus.

Potential Gene Biomarker Discovered for Lupus Diagnosis and Evaluation

Researchers have identified ELF1, a potential gene biomarker for diagnosing systemic lupus erythematosus (SLE). This discovery, based on genetic data from Chinese participants, highlights ELF1's role in assessing disease activity and renal involvement. Further studies are needed to confirm ELF1's regulatory mechanisms in SLE progression.

Health Spotlight’s Systemic Lupus Erythematosus is a Contentive publication in the Healthcare division